I'm using Charge, Nova, and Pull, and went with all the melee upgrades. I use the Asari sword. I haven't tried most of the other melee wepons, but the asari sword has pretty long range, and you teleport around, which i'm pretty sure prevents you from being damaged sometimes.
I rarely use my wepons, but they are the Mattock AR, and some sniper which I forget the name of. The sniper is useful for big bosses that I don't wanna get super close to, and for letting me charge at people from longer distances.
As far as squadmates go, I too use PeeBee and whoever seems appropriate. Which seems to be Jaal a lot.
When I grow up to be a Waterfall, I'm gonna wear a helmet.